All of this essentially intensifies migraine pain and plays a role in triggering a migraine.ĬGRP has been studied since the early 1980s when it was discovered. In fancy headache specialist circles, you’ll hear this called “sterile neurogenic inflammation”. It increases pain transmission and is a very potent inflammatory protein. It is also a potent vasodilator (dilates blood vessels) which triggers more CGRP release and pain. What is Calcitonin Gene Related Peptide (CGRP), and how does CGRP relate to migraine?ĬGRP plays a strong role in neurogenic inflammation in the nervous system and is involved in the transmission of pain. Other migraine preventive therapies include neuromodulation devices, Botox injections, or alternative treatments such as vitamins and supplements, acupuncture, acupressure and pressure points, or yoga and meditation. The gepants (Nurtec, Qulipta) have also now received FDA approvals for migraine preventive treatment. Unfortunately, there were still many migraine patients that did not respond to these conventional options, or had side effects with them. These conventional migraine preventive treatments are still used, can be very effective, and are discussed in much greater detail here. Prior to 2018, all of the migraine preventive medication options had been “adopted” from other specialties.įor example, the 3 main categories of preventive medicines prior to 2018 were select evidence-based options within the anticonvulsant (anti-seizure), anti-depressant/anti-anxiety, and anti-hypertensive (blood pressure) medicine categories. So it finally happened! The 1 st migraine specific preventive medications FINALLY became available with the CGRP (calcitonin gene related peptide) monoclonal antibody (CGRP mAb) antagonists which first came to market in Spring of 2018.
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